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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1A
All Species:
10.61
Human Site:
Y281
Identified Species:
17.95
UniProt:
O15047
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15047
NP_055527.1
1707
186034
Y281
T
S
R
G
S
T
P
Y
S
Q
D
S
A
Y
S
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
Y281
T
S
R
G
S
T
P
Y
S
Q
D
S
A
Y
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_848999
1330
145541
D25
R
N
Y
K
L
I
V
D
P
A
L
D
P
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
S289
F
S
Q
D
S
S
Y
S
S
R
Q
P
T
P
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506028
1287
141359
Chicken
Gallus gallus
Q5F3P8
2008
223067
R340
K
F
T
D
A
Y
N
R
R
P
G
G
H
H
Y
Frog
Xenopus laevis
Q66J90
1938
216239
S307
S
Q
D
S
S
Y
S
S
R
Q
T
T
P
A
F
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
G326
S
S
Y
S
S
R
Q
G
T
P
A
F
Q
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
M283
S
Y
D
R
D
R
G
M
R
E
N
V
G
T
S
Honey Bee
Apis mellifera
XP_395451
1406
159180
P101
P
E
V
Q
P
R
D
P
R
S
Q
L
T
R
I
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
D202
T
K
C
T
P
R
I
D
P
F
L
S
I
L
N
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
S347
P
A
I
S
Q
D
P
S
A
V
N
F
Q
A
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38827
1080
123894
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
S8
M
S
R
S
S
G
A
S
F
A
Q
F
F
P
A
Conservation
Percent
Protein Identity:
100
99.5
N.A.
73.2
N.A.
37
N.A.
N.A.
27.7
34.5
34.1
36.7
N.A.
25.6
24.6
20.9
23.7
Protein Similarity:
100
99.5
N.A.
74.7
N.A.
49.5
N.A.
N.A.
38.7
47.5
48.6
50.7
N.A.
41.3
39.6
35.8
39.2
P-Site Identity:
100
100
N.A.
0
N.A.
26.6
N.A.
N.A.
0
0
13.3
13.3
N.A.
6.6
0
13.3
6.6
P-Site Similarity:
100
100
N.A.
6.6
N.A.
46.6
N.A.
N.A.
0
13.3
26.6
33.3
N.A.
26.6
0
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.7
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
33.8
36.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
8
0
8
15
8
0
15
29
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
15
15
8
8
8
15
0
0
15
8
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
8
8
0
0
0
0
0
0
8
8
0
22
8
0
8
% F
% Gly:
0
0
0
15
0
8
8
8
0
0
8
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% H
% Ile:
0
0
8
0
0
8
8
0
0
0
0
0
8
0
8
% I
% Lys:
8
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
0
0
0
0
15
8
0
8
8
% L
% Met:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
8
0
0
0
15
0
0
0
15
% N
% Pro:
15
0
0
0
15
0
22
8
15
15
0
8
15
15
0
% P
% Gln:
0
8
8
8
8
0
8
0
0
22
22
0
15
0
0
% Q
% Arg:
8
0
22
8
0
29
0
8
29
8
0
0
0
8
0
% R
% Ser:
22
36
0
29
43
8
8
29
22
8
0
22
0
0
29
% S
% Thr:
22
0
8
8
0
15
0
0
8
0
8
8
15
8
8
% T
% Val:
0
0
8
0
0
0
8
0
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
15
0
0
15
8
15
0
0
0
0
0
15
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _